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CSBio Peptides and Instrumentation are found in Premier Science Publications Worldwide

Automated Peptide Synthesizers

RESEARCH SCALE

●Our research scale peptide synthesizers can be used for R&D, process development, and small scale manufacturing. With our patented 180o inversion mixing, we provide complete resin to solvent contact while synthesizing your peptide.

CSBio II

CS136X

CS136M

PILOT SCALE

●Our pilot scale synthesizers are designed for process development, scale up, and single batch clinical and commercial manufacturing.

●Utilizing overhead stirring with reaction vessel sizes ranging from 200ml to 5L.

●Our pilot scale systems provide consistency in developing processes for commercial manufacturing.

CS536X

CS936S

COMMERICIAL SCALE

The CS-OLIGO-D is a fully automated DNA/RNA oligonucleotide synthesizers that can be used from research, process development and production.

●Our large scale systems are the largest automated peptide synthesizers available worldwide.

●Each system is designed and manufactured to customer specifications, tailored to specific peptide needs.Reaction vessels range from 5L to 500L.

CS936

CS936X

CS936X

CSBIO'S SYNTHESIZER - SEAMLESS SCALE-UP

Peptide Cleavage Systems

CSBio provides users with different sizes of Peptide Cleavage Systems to meet peptide manufacturing requirement, the size starts from 10L to 100L.

The CS936 Automated Peptide Synthesizer Cleavage System of the following units.

1. Synthesizer Unit: Contains the reaction vessel, agitator, air and nitrogen meters, pumps and valves.

2. Controller box unit: Holds the power supply and controller card.

3. Computers and monitors. CSPEPM software is easy to operate.

CSPEP SOFTWARE 

DNA/RNA Synthesizer

CS-OLIGO-D

This system is equipped with a reaction vessel that has 180° inversion mixing, flow through, and reaction vessel recirculation capabilities.Traditional flow through DNA synthesis, and recirculation for RNA synthesis.

OLIGO-D

OLIGO-A

LC Purification

●Free standing Autoprep HPLC system for sequentially purification of up to 8 product samples to be purified

●Intuitive software for ease of use

●UV detection

●Dedicated sample loading pump (unlimited volume to load, not a sample loop)

●3 columns (free choose which column to use for any specific peptide)

●Fraction collectors with a dedicated tray for each peptide

●Up to 100ml/minute flow rate per pump

PEPTIDE & DNA/RNA REAGENTS

Complete range of peptide and DNA/RNA reagents used in the production of non-GMP and GMP peptides!

Our Peptide Reagents are validated as per USFDA GMP Guidelines! Quality Guaranteed!

●Amino Acids and Derivatives 

●Amino Alcohols 

●Linkers for Peptide Synthesis

●NN-Protecting Reagents

●Peptide Coupling Reagents& Peptide Reagents

●Special Amino Acids

●Pseudoproline Building Blocks

●Peptide Resins

●PET Peptide Reagents

●DNA/RNA Reagents

Custom Peptides

●Our custom peptide services is able to meet your R&D and screening requirement. 

●We specialized in Difficult Peptides with sophisticated sequences and modification.

Our Peptide Modification List

●Fluorescence/Dye Labeling

●Special amino acid

●Isotope labeling

●Linker

●Methylation

●Cyclization

●Phosphorylation

PET PEPTIDES

●Targeted probes made up of bifunctional reagents linked both peptides and chelate metallic elements can be used in molecular imaging techniques for cancer therapy.

●Also can be used in screening, identification and classification of tumor markers.

●CSBio can provide many kinds of bifunctional reagents and PET peptides.

Peptide Vaccine/ Immunotherapy

●Material supply for Nature paper ("An immunogenic personal neoantigen vaccine for patients with melanoma")

●Provided peptides for >100 patients in clinical studies

●Unique instrumental set-up due to backwards integration in specifically designed peptide synthesizer (simultaneous peptide synthesis) and dedicated GMP suites

●Assisted in successful FDA IND filing (CSBio is holding DMFs for personalized peptide vaccines)

●In 2021 CSBio was awarded as Supplier of the Year from the company Vaxxinity

GMP MANUFACTURED PEPTIDES

●CSBio features a full service FDA inspected GMP peptide production facility with a primary focus on custom and GMP peptide production.

●Our commitment to quality and compliance is a driving force behind our operations.

COMMERCIAL PEPTIDES

●Has recently received a Recommendation for Approval commercial production of Exenatide to produce commercial API following a vigorous FDA audit

●Our value added services include process development, scale up production, analytical/process validation, stability studies, CMC, DMF, and FDA regulatory support

●We would certainly welcome any members of your staff to visit our facility for an audit/inspection

CLINICAL PEPTIDES

●Our state of the art cGMP facilities were built specifically for GMP peptide production.

●Our team is well versed in guiding our clients through the clinical process to assure that all requirements are met whether you require a single cGMP grade peptide or multiple cGMP grade peptides for peptide vaccine or clinical comparison studies

CSBio Introduction 

CSBio is Global peptide company bringing 30 years of technical expertise into the peptide industry  which cover four main categories of products and services:

1) peptide CRDMO service -GMP and R&D peptide production, with API peptide production approved by USFDA

2) Peptide Instrumentation - from R&D up to Large Scale Manufacturing-type synthesizer, Cleavage systems, PreHPLC system, Column packing equipment and peptide production technical support

3) Peptide raw material -- High Quality Standard Grade and High Grade Fmoc-protected Amino Acid, peptide reagents, coupling reagents, resins and special reagents, supported by relevant validated QC data, stability data and DMF technical documents.

4) DNA/RNA oligonucleotide synthesizers that can be used from research、process development and production

CSBio (Shanghai) Ltd

China (Shanghai) Pilot Free Trade Zone, 85 Faladi Road, Building 2, Room 502 ,Shanghai 201210, China

Tel：+8621-50781653/50781655

Fax：+8621-50781652/021-50781656

Website：www.yihekuaiji.com www.csbio.com